Process for the separation of ursodeoxycholic acid from chenodeoxycholic acid and products obtained during the process

摘要

A mixture of ursodeoxycholic acid and of chenodeoxycholic acid as well as of their salts and esters is reacted with a silylating agent in a suitable anhydrous organic solvent; the corresponding silyl-derivatives thus obtained are separated by crystallization and pure ursodeoxycholic acid is recovered from the corresponding silyl-derivatives in the usual manner.