wherein X is chloro or fluoro, by the strong acid solvolysis of an alpha-methylbenzylhydantoin of the formula:-;Also disclosed is a process for preparing compound (I) from a halochromanone oftheformula:-which processes proceeds through intermediate (V). Also covered are novel intermediates prepared in the above process, and the novel chiral hydantoin of the formula (I) in which X is chloro and a pharmaceutical composition containing it."/>
Process for the preparation of chiral hydantoins, novel intermediates useful therein, and a novel hydantoin produced by said process and a pharmaceutical composition containing it
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Process for the preparation of chiral hydantoins, novel intermediates useful therein, and a novel hydantoin produced by said process and a pharmaceutical composition containing it
Process for the preparation of chiral hydantoins, novel intermediates useful therein, and a novel hydantoin produced by said process and a pharmaceutical composition containing it
A process for preparing a chiral hydantoin aldose reductase inhibitor of the formula:wherein X is chloro or fluoro, by the strong acid solvolysis of an alpha-methylbenzylhydantoin of the formula:-;Also disclosed is a process for preparing compound (I) from a halochromanone oftheformula:-which processes proceeds through intermediate (V). Also covered are novel intermediates prepared in the above process, and the novel chiral hydantoin of the formula (I) in which X is chloro and a pharmaceutical composition containing it.
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机译：制备下式的手性乙内酰脲醛糖还原酶抑制剂的方法： <图像文件=“ IMGA0001.GIF” he =“ 23” imgContent =“ chem” imgFormat =“ GIF” inline =“ no” wi =“ 70” /> 其中X通过下式的α-甲基苄基乙内酰脲的强酸溶剂解是氯或氟 <图像文件=“ IMGA0002.GIF” he =“ 26” imgContent =“ chem” imgFormat =“ GIF” inline =“ no” wi =“ 78” /> ;也公开了一种由式的卤代苯并二氢吡喃酮制备化合物（I）的方法： <图像文件=“ IMGA0003.GIF” he =“ 22” imgContent =“ chem” imgFormat =“ GIF” inline =“ no” wi =“ 62” /> 处理继续通过中间体（V）。还涵盖了通过上述方法制备的新型中间体，以及其中X是氯的式（I）的新型手性乙内酰脲和包含它的药物组合物。
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