AN INDUCIBLE DNA REPLICATION-CELL DIVISION COUPLING MECHANISM IN ESCHERICHIA COLI

摘要

The invention relates to a recombinant of a sfi gene and of a gene encoding for an enzyme liable of being dosed, such as the lacZ gene, as well as to cells transformed by said recombinant. The cells are useful for the detection of the mutagenic power of a tested substance, by cultivation of said transformed cells in the presence of said substance and the dosage of the enhancement of production of said enzyme, if any, whereby said enhancement is correlatable to the mutagenic power of the tested substance.