Title compds. I [R=C1-5 alkyl, hydroxy, C1-3 alkoxy, etc. are prepd. Thus, 6.92g 3,3-dimethyl-5-(4-chlorobutoxy)indolinone-2 is treated with a mixt. contg. 5.46 g 4-cyclohexylthiophenol, 7.13g anhyd. K2CO3, and 60 ml dimethyl sulfoxide with stirring. The resulting mixt. is treated with 500 ml ethyl acetate to give 8.0g 3,3-dimethyl- 5-[4-(4-cyclohexylphenylmercapto)butoxy indolinone-2. This compd. is useful for the prevention of cancer cell transmission.
展开▼
