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Optically pure (alpha) - amino phenyl acetic acid derivatives, processes for their preparation and their use for the preparation of medicaments

机译:光学纯的(α)-氨基苯基乙酸衍生物,其制备方法及其在药物制备中的用途

摘要

Optically pure alpha -aminophenylacetic acids which are substituted on the alpha -phenyl ring, of the general formula I IMAGE in which R1, R2, R3, R4, R5, R6 and n are as defined in the description, an enzymatic process for their preparation by stereoselective cleavage of suitable racemic derivatives of the abovementioned amino acids, followed by conversion into the D- or L-amino acids, and their use as intermediates in the preparation of medicines.
机译:通式I 的在α-苯环上取代的旋光纯α-氨基苯基乙酸,其中R 1,R 2,R 3,R 4,R 5 ,R 6和n,如说明书中所定义,其是通过立体选择性切割上述氨基酸的合适外消旋衍生物,然后转化为D-或L-氨基酸来制备它们的酶促方法,以及它们的用途药物制备的中间体。

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