Amino Acid Derivatives of furan - il - 2 - substituted acetic acid or amino Tien - il - 2 - substituted acetic acid, Process for their preparation, medicaments containing them,Use of these compounds for the preparation of medicaments for the Treatment

摘要

Refers to - amino acid Derivatives of furan - il - 2 - substituted acetic acid or amino acid - 2 - substituted the formula I where a is o, S; r1 is C1 - C6 alkyl aryl, aryl, heterociclilo,(C1 - C6 alkyl) - heterociclilo; R2 is H, alkyl C1 - C3, C8 - C12 cycloalkyl alkyl, cycloalkyl, C1 - C6 C3, C8, C6 C1 - aryl alkyl, aryl, alkyl heterociclilo, C1 - C6 heterociclilo; R3, R4, R5 are h,Oh, sh, F, CL, BR, NO2 - C12 cycloalkyl alkyl C1, C3, C8, sir6r7r8 - (CH2) - or - (CH2) M - (CH2) R9; or - SP - (CH2) Q - R10, S (CH2) - ocor12 cor13; between; Other; n, m, Q, s are 0 OR 1 - 4 - 4 - 2; p is 1; R6, R7,R8 are c1-c6 alkyl, phenyl, R9 and R10 are h, CH3, heterociclilo co alkyl, aryl, C1 - C6 - aryl - aryl, co; R11 is H, alkyl phenyl - C1 - C6, CH2; R12 is c1-c6 alkyl, aryl; R13 is H, alkyl of C1 - C6,Aryl, heterociclilo, nr14r15 R14 and R15 is H, alkyl, cycloalkyl C3 C1 - C6, C8, among others.Preferred compounds are acid (5 - metilsulfanilmetil - furan - 2 (IL -) - 5 - nitro - pyridin-2-yl - amino) - acetic acid (5 - bromopirimidin; ilamino - 2 - (5) - - - - metilsulfanilmetilfuran 2 yl) - acetic acid, among others.It also relates to a process for Preparation. The compounds may be useful for the treatment of Pain and migrana