Magnesium senegenate anti:allergic and anti:leukaemic agent - is prepd. by treating senegenine with magnesium carbonate

摘要

Magnesium senegenate (I), is obtd. by hot extraction of roots of Securidaca longepedonculata to give an extract rich in senegenine (II). This extract is then treated with magnesium carbonate in an aqueous medium to give (I). Anti-allergic agent for treatment of eozemas, psoriasis, asthma, and rhino-sinusitis, maintenance of remissions from plate scleroses and treatment of chronic lymphoid leukaemia. (II) is a known agent for eczema and psoriasis, but it can only be given orally and has an immunodepressant effect. (I) is more soluble and may be given by injection as well as orally. Its immunodepressant effect is minimal. The adult daily odsage is 100-600mg orally or 50-30 mg by injection.