Pharmacologically active 1,3-bis (2-heterocyclyl-methyl-thio) ethyl)ethyl) guanidino!alkane derivatives

摘要

The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'- substituted guanidino), N-(N', N"-disubstituted guanidino), N-(N'- substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido) groups. Two compounds of the invention are 1,3-bis N'-(2- (3-methoxy-2- pyridylmethylthio)ethyl)guanidino!propane and 1- N-(2-(3- methoxy- pyridylmethylthio)ethyl)guanidino!-3- N'-2-(5-methyl-4- imidazolylmethylthio)ethyl)guanidino!propane. The compounds of this invention are inhibitors of H-2 histamine receptors.