TOCOPHEROL AND PREPARATION OF PARTICULARLY D-ALPHA- TOCOPHEROL, INTERMEDIATE PRODUCT OF SAID METHOD AND APPLICATION THEREOF

摘要

PURPOSE:To obtain the titled substance, by separating a metallic carbonyl part from a reaction product of a carbonyl-alkenylcarbenemetallic complex with an alkynol, removing the ether from the metallic carbonyl part, and cyclizing the resultant product in the presence of an acidic catalyst. CONSTITUTION:A carbonyl-alkenylcarbene-metallic complex having substitutent groups R1 and R2 linked to the alkenyl group and an ether type substituent group R3 [R1 is CH3 or OCH3; R2 is H, CH3 or OCH3; R3 is CH3, C2H5, COR or SiR3 (R is alkyl, aryl or alkylaryl)], e.g. the compound of formula I , is reacted with a compound of formula II (R4 is H or CH3; R5 is [(CH2)3CHCH3]3CH3, etc.), to give a compound of formula III, and the metallic carbonyl part is then separated therefrom to afford a compound of formula IV, etc. The resultant compound of formula IV is then subjected to the removal of the ether and then cyclized in the presence of an acidic catalyst to give the titled substance (natural vitamine E). The compounds of formulas III and IV are novel substances.