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TOCOPHEROL AND PREPARATION OF PARTICULARLY D-ALPHA- TOCOPHEROL, INTERMEDIATE PRODUCT OF SAID METHOD AND APPLICATION THEREOF
TOCOPHEROL AND PREPARATION OF PARTICULARLY D-ALPHA- TOCOPHEROL, INTERMEDIATE PRODUCT OF SAID METHOD AND APPLICATION THEREOF
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机译:生育酚及其特别是D-α-生育酚的制备,所述方法的中间产物及其应用
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PURPOSE:To obtain the titled substance, by separating a metallic carbonyl part from a reaction product of a carbonyl-alkenylcarbenemetallic complex with an alkynol, removing the ether from the metallic carbonyl part, and cyclizing the resultant product in the presence of an acidic catalyst. CONSTITUTION:A carbonyl-alkenylcarbene-metallic complex having substitutent groups R1 and R2 linked to the alkenyl group and an ether type substituent group R3 [R1 is CH3 or OCH3; R2 is H, CH3 or OCH3; R3 is CH3, C2H5, COR or SiR3 (R is alkyl, aryl or alkylaryl)], e.g. the compound of formula I , is reacted with a compound of formula II (R4 is H or CH3; R5 is [(CH2)3CHCH3]3CH3, etc.), to give a compound of formula III, and the metallic carbonyl part is then separated therefrom to afford a compound of formula IV, etc. The resultant compound of formula IV is then subjected to the removal of the ether and then cyclized in the presence of an acidic catalyst to give the titled substance (natural vitamine E). The compounds of formulas III and IV are novel substances.
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机译:目的:通过从羰基-烯基碳烯金属配合物与炔醇的反应产物中分离出羰基金属部分,从羰基金属部分去除醚,然后在酸性催化剂的存在下环化所得产物,来获得标题物质。组成:一种羰基-烯基碳烯-金属配合物,其取代基R1和R2与烯基相连,醚型取代基R3 [R1为CH3或OCH3; R 2为H,CH 3或OCH 3; R 3是CH 3,C 2 H 5,COR或SiR 3(R是烷基,芳基或烷基芳基)],例如。使式I的化合物与式II的化合物(R 4为H或CH 3; R 5为[(CH 2)3 CHCH 3] 3 CH 3等)反应,得到式III的化合物,然后羰基的金属部分为然后将得到的式IV化合物除去醚,然后在酸性催化剂存在下环化,得到标题物质(天然维生素E)。式III和IV的化合物是新物质。
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