naphthylglycyl and tetrahydronaphthylglycyl - cephalosporin antibiotics and procedure for its manufacture

摘要

PROCEDURE FOR THE OBTAINING OF CEPHALOSPORINS AND THEIR PHYSIOLOGICALLY COMPATIBLE SALTS, OF FORMULA (I), IN WHICH A AND B ARE HYDROGEN OR TOGETHER FORM A DOUBLE LINK; R1-R6 MAY BE SEVERAL TYPES OF RADICALS, CONSISTING IN THE REACTION OF CLARIFICATION OF A COMPOUND OF FORMULA (II) WITH A CLARIFYING AGENT OF FORMULA (III), OR AN ACTIVE DERIVATIVE OF THE SAME, IN WHICH ALL THE SYMBOLS HAVE THE SAME MEANING THAT IN THE FORMULA (I). THE ACILATION IS CARRIED OUT IN A COMMON ORGANIC SOLVENT, INERT, IN THE PRESENCE OF A BASE, AT A TEMPERATURE INCLUDING BETWEEN C20ºC AND 60ºC. THESE COMPOUNDS HAVE PHARMACOLOGICAL APPLICATIONS FOR THE TREATMENT OF BACTERIAL DISEASES. (Machine-translation by Google Translate, not legally binding)