PROCESS FOR PRODUCING AQUEUS SOLUTUINS OF WATER INSOLUBLE OR HARDLY SOLUBLE VITAMINES, STEROIDES, LOCALANESTHETICS, PROSTANOIDES AND NON-STEROID AND ANTIPHLOGISTIC AGENTS

摘要

The invention relates to water-soluble inclusion complexes of biologically active organic compounds which are insoluble or have only limited solubility in water, particularly of fat-soluble vitamins, steroid hormones, prostanoids, local anaesthetics and the like, to their aqueous solutions and to their preparation, wherein the biologically active compounds are converted into an aqueous solution in the form of inclusion complexes which have been formed with dimethyl- beta -cyclodextrins having an average degree of substitution of 14, in particular with heptakis(2,6-di-O-methyl)- beta -cyclodextrin, by dissolving the organic compounds which are insoluble or have only limited solubility in water in an aqueous solution of 1 to 8 mol (calculated per 1 mol of the compound to be dissolved) of dimethyl- beta -cyclodextrin. The aqueous solutions, obtained according to the invention, of the biologically active organic compounds can be processed to give pharmaceutical products which can be administered orally or parenterally.