METHOD OF TREATING 2-ALPHA-CYANO-4-ALPHA 5-ALPHA-EPOXY-3-OXO-STEROID COMPOUNDS AND A PROCESS FOR THE PREPARATION OF PHARMACEU-TICAL COMPOSITIONS CONTAINING THE SAME WITH A CONTROLLED PARTICLE SIZE

摘要

The present invention relates to certain steroid compounds in which the particle size of the active compound is controlled in order to obtain a higher and more acceptable level of in vivo activity. The steroid compounds are those having a basic ring structure of the general formula: CHEM in particular that known as "trilostane", the compounds being in particulate form and consisting of particles having a mean equivalent sphere volume diameter of less than about 20 mu m, at least 95% of the particles having a particle size of less than about 50 mu m.