PROCESS FOR RESOLVING DERIVATIVES OF 5-(2-FLUORYL)-5-(2-THENOYL)-5-(3-FUROYL)-AND 5-(3-THENOYL)-1,2-DIHYDRO-3H-PYRROLO(1,2-A)-PYRROL-L-CARBOXYLIC ACID INTO (L)-ACID ISOMERS AND (D)-ACID ISOMERS THEREOF

摘要

Carboxylic acid esters of the formula IMAGE are prepared by condensation of a compound of the formula IMAGE with an amide of the formula IMAGE In the formulae, X represents oxygen or sulphur, R represents hydrogen or C1-C4-alkyl, R1 represents hydrogen, methyl, chlorine or bromine and R2 represents C1-C4-alkyl. Hydrolysis of the carboxylic acid esters results in the corresponding carboxylic acids and their salts. The compounds are novel and exhibit an anti inflammatory, analgesic and antipyretic action. They are suitable in particular for treating inflammations, pain and febrile conditions.