process for the preparation of acid alpha idrossiaril - alcanoici.

摘要

A process is described for the preparation of alpha-hydroxyl-alkanoic acids of formula IMAGE (I) which are known anti-inflammatory agents or intermediates for known pharmaceutical products. The process consists essentially in the rearrangement of phenolates of formula IMAGE (II) wherein Ar is an unsubstituted or substituted phenyl or naphthyl, in aqueous environment or in an organic medium, at temperatures comprised within the range of from 0 DEG to 100 DEG C. and within short times, followed by either acid or alkaline hydrolysis.