New Method for Preparation of cyclic imines and their acid Addition Salts and Quaternary Salts.

摘要

Process for the preparation of cyclic imines, of General formula (i), in which B is oxogeno or imino; x1 and x2 represent Hydrogen or lower alkyl, halogen, alkoxyl; and N Is 6 or 7, and their acid Addition Salts and Quaternary salts, pharmaceutically acceptable.Involves reacting a compound of formula (ii), in which X1, x2 and B have the meanings already mentioned; R1 and R2 is Hydrogen, halogen, a compound of formula (iii), which has the meaning as described above. The Compound thus obtained can be converted into a adicionbasica or pharmacologically acceptable Salt, a Quaternary Salt.Application in the preparation of pharmaceutical compositions used in treatment of cardiovascular diseases.