2-PIPERAZINEPYRIMIDINE DERIVATIVES; PROCESS FOR PREPARING THE SAME AND THEIR USE AS THERAPEUTIC AGENTS OR INTERMEDIATE PRODUCTS FOR THE MANUFACTURE OF THERAPEUTIC AGENTS

摘要

SPECIFIC The invention relates to novel piperazino-2 pyrimidine derivatives having the general formula: (I) wherein X is a hydrogen or chlorine atom or an alkyl, alkoxy or alkylthio having 1 to 3 carbon atoms, R2 is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, Y2 is a chlorine atom and Y1 is a chlorine atom or a group wherein R1 is a hydrogen atom, an alkyl group straight or branched having 1 to 7 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms or a cycloalkyl-alkyl group having 4 to 8 carbon atoms, or Y2 and Y1 are both OH. The compounds according to the in-vention are useful either as intermediates for the manufacture of medicaments, or as anti-hypertensive drugs, antimigraine agents, antidepressants or as drugs for the treatment of senescence, the dis-die or Parkinson symptoms observed during opiate withdrawal.