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PROTHROMBIN-CONTAINING THERAPEUTIC COMPOSITIONS AND METHODS OF PRODUCING ENZYMATICALLY ACTIVE BLOOD CLOTTING FACTORS FROM PROTHROMBIN-CONTAINING BLOOD FRACTIONS
PROTHROMBIN-CONTAINING THERAPEUTIC COMPOSITIONS AND METHODS OF PRODUCING ENZYMATICALLY ACTIVE BLOOD CLOTTING FACTORS FROM PROTHROMBIN-CONTAINING BLOOD FRACTIONS
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机译:含凝血酶原的治疗性组合物和从含凝血酶原的血液馏分中生产酶促活性凝血因子的方法
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摘要
An improved method for producing activated prothrombin complex concentrate which comprises controlling the degree of activation by determining the activation state of the starting material and then varying at least one of the activation conditions in accordance with analyses of the progress of activation or the starting material to arrive at a predetermined activation level. Compositions including, in units/ml, factor VIII correctional activity, about from 2-35; prothrombin, about from 1-10; thrombin, less than about 0.003; factor VII, about from 37-190; factor VIIa, about from 8-80; total factor IX, about from 15-112; factor IX precursor, 0 to about 30; factor X, about from 1-30; and factor Xa, about from 1-10 are used in therapeutically effective amounts to treat blood clotting factor inhibitors.
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