PROBE CONTAINING A MODIFIED NUCLEIC ACID RECOGNIZABLE BY SPECIFIC ANTIBODIES AND UTILIZATION OF SAID PROBE TO TEST FOR AND CHARACTERIZE AN HOMOLOGOUS DNA SEQUENCE

摘要

A method of detecting the presence of a nucleic acid sequence such as a gene or gene fragment in a composition or sample presumed to contain it. It is characterized in that one puts in contact the composition with a probe containing a nucleic acid complementary to the nucleic acid sequence or gene sought under conditions enabling hybridization this particular, said probe having at least one N- 2-acetylaminofluorene covalently attached to at least one of the bases of this probe, the possible presence of the nucleic acid sequence or gene of interest is then revealable by the action of antibodies effective vis-à-vis N-2- (guanosine-8-yl) -acétylaminofluorène or previously prepared vis-à-vis the probe bearing acetylaminofluorene residues of.