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Controlled release theophyllin tablets and process for producing them
Controlled release theophyllin tablets and process for producing them
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机译:控释茶碱片及其生产方法
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摘要
1. Pharmaceutical tablet constituted by a hydrophilic polymeric matrix permitting controlled and constant release of a unitary therapeutic dose of theophyllin during a period of approximately 12 hours, of the type comprising at least one polymer derived from cellulose and a lubricating agent, characterised in that it contains : . an effective therapeutic quantity of theophyllin ; . from 18% to 35% by weight as a ratio of the total weight of the tablet of at least one hydroxypropylmethylcellulose by way of hydrophyllic polymer, the hydroxypropylmethylcellulose(s) having a viscosity of 2% weight for weight at 20 degrees C between 10**-1 Pa s and 15 Pa .s ; . from 7.5% to 22.5% by weight as a ratio of the total weight of the tablet of lactose favouring hydration of the polymer, and . 0.5% to 1% by weight as a ratio of the total weight of the tablet of an internal hydrophobic lubricating agent, and in that the weight ratio of the theophyllin expressed in anhydrous weight as a ratio to the polymer is between 1 and 3.
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机译:1.由亲水性聚合物基质构成的药物片剂,其允许在约12小时内控制和恒定地释放单一剂量的茶碱,其类型包括至少一种衍生自纤维素和润滑剂的聚合物,其特征在于,包含:。有效治疗量的茶碱; 。至少18%至35%的重量,以至少一种羟丙基甲基纤维素的片状总重量的比例通过亲水性聚合物制成,该羟丙基甲基纤维素在20摄氏度下的重量粘度为2%,在10 * * -1 Pa s和15 Pa.s; 。占片剂总重量的比例为7.5重量%至22.5重量%,有利于聚合物的水合作用;和内部疏水性润滑剂的总重量占片剂总重量的比例为0.5%至1%,而以无水重量表示的茶碱与聚合物的重量比为1-3。
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