HYDROXYPHENYL-THIAZOLE-THIAZOLINE AND -THIAZOLIDINE CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND THESE COMPOUNDS FOR USE IN INFLUENCING THE COLLAGEN METABOLISM

摘要

What are disclosed are hydroxyphenyl-thiazole-, -thiazoline- and -thiazolidine-carboxylic acids of the formulae IMAGE (I) and IMAGE (II) in which R1 and R3, independently from each other, are hydrogen, methyl, chlorine or bromine, and R1 and R3 may alternatively be nitro, amino or sulfonylamido; R2 is hydrogen, hydroxyl or methyl; R4 is hydrogen or methyl; and R5 is hydrogen, methyl, phenyl or -COOH; and their salts with physiologically acceptable bases, a process for the preparation thereof and their use for influencing the collagen metabolism.