Fermentative prodn. of indane type cpds. - by contacting a strain of Nocardia with a medium contg. sterol(s)

摘要

Prodn. of indane cpds., i.e. 3a-H-4-(3'-propionic acido)-5-hydroxy-7a-methyl-hexanhydro-1-indanone and 3a-H-4-(3'-propionic acido)-5-hydroxy-7a-methyl-hexahydro-1-indanone-8-lactone (HIL), comprises culturing a strain of Nocardia on a medium contg. sterols (e.g. cholesterol, beta-sitosterol, campesterol, liethocholic acid, cholic acid) or their dehydrogenated derivs., and recovering the prods. HIL is useful as an intermediate and recovering the prods. hormones, e.g. oestradiol. Suitable microorganism strains are e.g. Nocardia corallina NG-511 (FERM-P 4018), Nocardia corallina NG-34 (FERM-P 4017).