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Novel derivatives of the 2 - amino acid, thiazolyl 2 - oxyimino acetamido bicyclo - octene, their process of preparation and their application as medicinal products
Novel derivatives of the 2 - amino acid, thiazolyl 2 - oxyimino acetamido bicyclo - octene, their process of preparation and their application as medicinal products
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机译:2-氨基酸,噻唑基2-氧亚氨基乙酰胺基双环辛烯的新型衍生物,其制备方法及其在医药中的应用
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摘要
Novel syn isomers of optically active isomers and racemates of 7-[2-(2-amino-4-thiazolyl)-2-oxyimino-acetamido]-bicyclooctene-carboxylic acid derivatives of the formula IMAGE I wherein R is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and optionally substituted alkenyl and alkynyl of 2 to 6 carbon atoms, R1 is selected from the group consisting of hydrogen, methyl, halomethyl, hydroxymethyl and acyloxymethyl, X is selected from the group consisting of oxygen and optionally oxidized sulfur, A is selected from the group consisting of hydrogen, an alkali metal, -NH4, alkaline earth metal equivalent, a non-toxic, pharmaceutically acceptable organic amine and an easily cleavable ester group and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic activity and their preparation.
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