METHOD AND DEVICE FOR THE ENCAPSULATION IN ERYTHROCYTES OF AT LEAST ONE BIOLOGICALLY ACTIVE SUBSTANCE, IN PARTICULAR ALLOSTERIC EFFECTORS OF HEMOGLOBIN AND ERYTHROCYTES OBTAINED THEREBY

摘要

THE INVENTION RELATES TO A PROCESS OF ENCAPSULATION IN HUMAN OR ANIMAL ERYTHROCYTES OF AT LEAST ONE SUBSTANCE HAVING BIOLOGICAL ACTIVITY, CHARACTERIZED IN THAT IT IS CONTINUOUSLY FEEDED WITH AT LEAST ONE DIALYSIS ELEMENT WITH A SUSPENSION AQUEOUS ERYTHROCYTES, OF WHICH THE SECONDARY COMPARTMENT CONTAINS AN AQUEOUS HYPOTONIC SOLUTION IN RELATION TO THE SUSPENSION OF ERYTHROCYTES IN ORDER TO LYSY ERYTHROCYTES, IN THAT THE ERYTHROCYTE LYSATE IS THUS IN CONTACT WITH SUCH A SUBSTANCE AS PRESENT WHEREAS, IN ORDER TO RESELL THE MEMBRANE OF ERYTHROCYTES, THE OSMOTIC AND ONCOTIC PRESSURE OF ERYTHROCYTE LYSATE IS INCREASED AFTER ITS CONTACT WITH SUCH A SUBSTANCE WITH BIOLOGICAL ACTIVITY.