SURFACE GRAFTED PARTICLE SUPPORT, PROCESS FOR PREPARING THE SAME AND ADSORBENTS FOR AFFINITY CHROMATOGRAPHY INCORPORATING THE SAME, AND USE THEREOF, IN PARTICULAR IN BIOLOGY

摘要

THE PARTICULATE SUPPORT ACCORDING TO THE INVENTION FOR THE MANUFACTURE OF ADSORBENTS FOR AFFINITY CHROMATOGRAPHY IS ESSENTIALLY CONSISTING OF PARTICLES OF A BASE POLYMERIC MATERIAL SUITABLE FOR USE IN COLUMN CHROMATOGRAPHY AND ON WHICH ARE GRAFTED, ESSENTIALLY. AT LEAST ONE UNSATURATED MONOMER CAPABLE OF FORMING A COPOLYMER WITH THE BASIC MATERIAL AND CARRYING AT LEAST ONE CHEMICAL FUNCTION CAPABLE OF FORMING, SUBSEQUENTLY, IN NON-DENATURING CONDITIONS, A COVALENT LINK WITH THE LIGAND USED IN THE ADSORPTION ENVISAGED . /P P IT CAN BE PREPARED BY RADIO-CHEMICAL GRAFTING. /P P BY COVALENT FIXING ON THIS SUPPORT OF A LIGAND SPECIFIC TO THE SUBSTANCE TO BE ADSORBED, AN ADSORBENT FOR CHROMATOGRAPHY OF AFFINITY IS OBTAINABLE ESPECIALLY IN BIOLOGY, FOR EXAMPLE FOR THE PURIFICATION OF BLOOD.