PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL USE SOLUTION CONTAINING A NEW FER III POLYNUCLEAR MIXED COMPLEX AS ACTIVE INGREDIENT

摘要

PROCESS FOR THE PREPARATION OF A PHARMACEUTICAL USE SOLUTION CONTAINING A NEW FERINA POLYNUCLEAR MIXED COMPLEX AS AN ACTIVE INGREDIENT. The process according to the invention is characterized in that freshly precipitated ferric acid is readily available. LAVA IN A WAY TO BE FREE OF ANIONS IS DISSOLVED IN ACETIC ACID, THE ACETATE OF FERIII OBTAINED IN THIS MANNER IS MADE TO REACTION WITH A SUGAR ACID (0.25 TO 0.5 EQUIVALENT) AND DEXTRANE ( 0.25 TO 0.5 EQUIVALENT) OR WITH SUGAR ACID (0.5 TO 1.0 EQUIVALENT), THEN ACETIC ACID FORMED DURING THE REACTION IS REMOVED BY WATER VAPOR DISTILLATION, CONTINUE WATER VAPOR DISTILLATION UNTIL THE PH OF THE SOLUTION REACHES A VALUE OF 4.5 TO 5.0, THEN THE IRON CONCENTRATION IS ADJUSTED BY VACUUM DISTILLATION, THE SOLUTION IS THEN STERILIZED AND, POSSIBLY ADDED ADDITIVES OR ADJUVANTS.