Synergistic antibacterial compositions and method of treatment of infections caused by multiple antibiotic-resistant organisms

摘要

Antibiotic compositions comprising a 1-oxa -lactam antibiotic compound of the formula ##STR1## or pharmaceutically acceptable salts thereof and either tobramycin, amikacin or piperacillin exhibit synergistic activity against multiple-antibiotic-resistant organisms. The 1-oxa compound can be used in conjunction with tobramycin, amikacin or piperacillin in a method of treating infections caused by resistant organisms.