GRADUALLY RELEASING COMPLEX USING POLYDEPSIPEPTIDE AS CARRIER AND ITS PREPARATION

摘要

PURPOSE:A gradually releasing complex that is prepared by allowing physiologically active substances to be supported on polydepsipeptide, thus showing satisfactory performance in release of physiologically active substances, the decomposition of the carrier in vivo and mechanical properties. CONSTITUTION:Polydepsipeptide which is a linear polymer containing hydroxyacid units and aminoacid units as shown in the formula (n is 1-20; m is 0-20; x is larger than 2; R is residue of aminoacid; R' is residue of hydroxyacid) is used as a carrier and allowed to clathrate physiologically active substances. The polydepsipeptide and the physiologically active substances are mechanically mixed and formed into a desired shape under pressure of 10-10,000kg/cm2 at 20-400 deg.C or first polydepsipeptide is formed in a mold so that it has a cavity, the physiologically active substances are put in the cavity, then polydepsipeptide is charged in the mold full and pressed to give the objective complex.