AMINOPROPANOL DERIVATIVE, ITS PREPARATION, AND CARDIO- SELECTIVE AGENT FOR BLOCKING BETA-ADRENALIN ACTION CONTAINING SAID COMPOUND

摘要

NEW MATERIAL:N-[3-( 2-Flourophenoxy )-2-hydroxypropyl-N'-(1, 3-dimethy1-2, 4- dioxopyrimidyl(6)]-ethylenediamine of formula I and its acid addition salt. USE:A cardioselective beta-adrenaline-action blocking agent having extremely strong beta-blocking activity, remarkably high cardioselectivity and wide safety. PREPARATION:The objective compound of formula I can be prepared by reacting the compound of formula II with the compound of formula III optionally in an inert organic solvent. The starting compound of formula III can be obtained easily in high yield in crystalline form, by reactiong ethylenediamine with 1,3- dimethyl-6-chloropyrimidinedione(2,4) in dioxane at 10-100 deg.C.