METHOD FOR PRODUCING A MEANS FOR THE TREATMENT OF DISEASES INCREASED WITH CHANGES IN THE PULMONARY SURFACTANT SYSTEM

摘要

The invention relates to a process for the preparation of an agent for the treatment of diseases associated with changes in the pulmonary surfactant system, in particular the neonatal and adult respiratory distress syndrome. The recovery is carried out according to the invention by aqueous extraction of crushed Saeugerlunge and subsequent binding of the drug to a non-soluble adsorbent, especially silica gel or activated silicates. The elution of adsorbent is carried out with organic solvents or mixtures thereof. After concentration of the eluate to dryness, the active ingredient is emulsified in aqueous solution and lyophilized. The agent may be administered in the form of aerosol or as a bolus via the respiratory tract at a dose of 1-500 mg / ml physiological carrier fluid. It can be used in all respiratory diseases that are associated with a disturbance of the surfactant system. Its main ingredients are 20-75% phospholipids, 10-40% cholesterol and 5-30% neutral lipids. The protein content of the agent is less than 0.5%.