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6 - methylene - and 6 - hydroxymethyl - penicillansyrederivater and pharmaceutical preparations for the treatment of bacterial infections
6 - methylene - and 6 - hydroxymethyl - penicillansyrederivater and pharmaceutical preparations for the treatment of bacterial infections
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机译:6-亚甲基和6-羟甲基青霉酸脱敏剂和药物制剂,用于治疗细菌感染
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摘要
Beta-lactamase inhibiting compounds of the formula CHEM or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X3 is H or Br, R1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R12 and R13 is H and the other is vinyl, certain aryl, arythio, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxamido or amidino groups; one of R2 and R3 is H and the other is as diclosed for the other of R12 and R13, or is Cl or CH2OH, and R18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them.
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机译:式的β-内酰胺酶抑制化合物或其药学上可接受的酸加成盐或羧酸盐;其中n为零,1或2; X 3为H或Br,R 1为H,某些羧基保护基的残基或酯基的残基在体内易于水解; R 1 2和R 1 3中的一个为H,另一个为乙烯基,某些芳基,芳硫基,烷硫基,烷基磺酰基或某些杂环基,氨基甲基,硫代甲酰胺基或a基。 R 2和R 3中的一个为H,另一个与R 1 2和R 1 3的另一个相同,或为Cl或CH 2 OH,且R 1 <8>是H或某些酰基;在其生产中有用的中间体,其制备和使用方法以及含有它们的药物组合物。
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