Polycyclic hydrazones derived from 3-formylrifamycin SV as p or aldehydo component and a di- or tricyclic N-aminopiperazine as hydrazino-component as well as their preparation and use

摘要

Novel hydrazones derived from 3-formylrifamycin S or SV as the aldehyde component and a bi- or tricyclic N-aminopiperazine as the hydrazino component, of the formula IMAGE in which R1, R2, R3, R4, R5 and R6 independently each denote a hydrogen atom or C1-4-alkyl, m and n independently each denotes an integer from 0 to 5, X denotes C1-5-alkylidene, benzylidene or C1-4-alkoxymethylene, Y denotes C1-5-alkylidene, C1-4-alkoxymethylene, oxy, thio or optionally substituted imino of the formula -N(R)-, in which R represents hydrogen, C1-4-alkyl, C3-5-alkenyl, C3-12-cycloalkyl or phenyl, or X and Y together denote a 1,2-cycloalkylene or o-phenylene which can be substituted by 1-3 C1-4-alkyl radicals, and Rif denotes a radical of rifamycin S or SV bonding via the free valency in the 3-position, are distinguished by high and long-lasting antitubercular activity. They are prepared in a conventional manner, for example by condensation of their formation components.