Acetaminophen, following oral ingift tilvejebringerhurtigt onset of therapeutic action

摘要

A gelatin capsule for oral administration comprises a gelatin shell substantially encapsulating a physiologically compatible fill material, the fill material comprising an effective dosage amount of acetaminophen, a vehicle for the acetaminophen, a surfactant and a modifier for the vehicle, characterised in that:- (a) the vehicle comprises a low molecular weight polyethylene glycol having an average molecular weight of from about 400 to 1000 and a higher molecular weight polyethylene glycol having an average molecular weight of from about 1000 to about 10000, the acetaminophen being substantially evenly distributed through the vehicle; (b) the surfactant is of a type that is physiologically solubile and is in solution in the vehicle; and (c) the viscosity modifier is present in an amount equal to or greater than the amount necessary to gel the vehicle.