still for framstellning of seskviterpenderivat by cultivation of a microorganism tillhorande slektet stachybotrys

摘要

A sesquiterpene derivative expressed by the general formula (I): IMAGE (I) wherein R1 represents a hydrogen atom, a lower alkyl group or a lower alkanoyl group; R2 and R3, which may be the same or different, each represents a formyl group, a hydroxymethyl group, a hydroxyl group, a carboxyl group, a lower alkanoyloxymethyl group, or a group of the formula -CH=CR7R8, wherein R7 and R8, which may be the same or different, each represents a hydrogen atom, a cyano group, a lower alkoxycarbonyl group or a carboxyl group, or R2 and R3 may combine to form a lactone ring of the formula IMAGE in which R9 represents a hydrogen atom or a hydroxyl group; R4 and R6, which may be the same or different, each represents a hydroxyl group or a lower alkanoyloxy group; R5 represents a hydrogen atom; R4 and R5 may together form an oxo group (=O); and R4 and R6 may combine to form a lower alkylidenedioxy group, the pharmaceutically acceptable salts thereof, processes for the production of the compounds of the general formula (I) and the salts thereof, pharmaceutical composition containing the compounds of the general formula (I) and the salts thereof, and method of use of the compounds of the general formula (I) and the salts thereof.