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Highly soluble and stable basic pharmaceuticals in glyceride mixt. - are prepd. by converting to fatty acid salts by addn. of free fatty acid
Highly soluble and stable basic pharmaceuticals in glyceride mixt. - are prepd. by converting to fatty acid salts by addn. of free fatty acid
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机译:甘油酯混合物中的高度可溶且稳定的基础药物。 -准备。通过加成转化为脂肪酸盐。游离脂肪酸
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摘要
The solubility and stability of basic pharmaceuticals (I) in mixts. of mono- an di-glycerides of 6-12C fatty acids are improved by adding to (I) free 6-18C (6-10C) fatty acids. The resulting salts are then dissolved in the glyceride mixt. Better resorption of (I) from the gastro-intestinal tract. The fatty acid salts of (I) are more soluble in the glyceride mixt. than free bases or hydrochlorides.
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