Adenosine desaminase inhibitor isocoformycin - useful for potentiating antitumour and antibacterial activity of formycin and adenine arabinoside

摘要

Isocoformycin (3-beta-D-ribofuran osyl-3,6,7,8-tetrahydroimidazo 4,5-d 1,3 -diazepin-7-ol), of formula (I), is a new cpd:- (I) is an adenosine desaminase inhibitor useful for potentiating the antitumour and antibacterial activity of formycin and adenine arabinoside. It has higher activity han 9-beta-D-ribofuranosyl-6-hydroxymethyl-1,6-dihydropurine. In example, (I) is prepd. from 9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-6-hydroxymethyl-1,6-d- ihydropurine.