PHYSIOLOGICALLY ACTIVE TETRAPEPTIDESABSTRACTThis invention provides tetrapeptide derivativesof the formula (I):(I)wherein R1 and R2 are methyl, 1-methylethyl, 2-methylpropyl,1-hydroxyethyl, 2-carboxyethyl or 4-aminobutyl and Y iswherein R3 is methyl, 1-methylethyl, 2-methylpropyl,1-methylpropyl, hydroxymethyl, 1-hydroxyethyl, carboxy-methyl, 2-carboxyethyl, 4-aminobutyl, 3-guanidinopropyl,benzyl or p-hydroxybenzyl excluding the compounds in which R1and R2 are each 1-methylethyl and also R3 is carboxymethylor 2-carboxyethyl, the first and leftmost .beta.-amino acidmoiety in said tetrapeptide derivatives having the (2S,3R)-configuration and a primary amino group and the second,third and fourth .alpha.-amino acid moieties in said tetrapeptidederivatives having the L-configuration. These compoundshave an inhibitory activity on several types of amino-peptidases.
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