SYNTHETIC POLYPEPTIDE CORRESPONDING TO A PORTION OF THE HEAT-LABILE ENTERO-TOXIN OF ESCHERICHIA COLI, COMPOSITIONS AND METHODS THEREWITH

摘要

Synthetic polypeptides containing about 10 to about 35 amino acid residues corresponding in sequence to the amino acid residue sequence of about position 35 to about position 95 from the amino-terminus of the B-subunit of the heat-labile enterotoxin of Escherichia coli along with composite polypeptides containing the polypeptide sequence of the heat-stable Escherichia coli enterotoxin, as are polymers containing the synthetic polypeptide and composite polypeptide as repeating units. The polypeptides are useful as conjugates coupled to a carrier or as a polymer as the active ingredient of an inoculum to raise antibodies and for protecting an animal host against infection by heat-labile enterotoxin-producing bacteria.