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Use of some 2-2-4-phenyl-1-piperazinylethyl-1H-naphth-1,2-dimidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases
Use of some 2-2-4-phenyl-1-piperazinylethyl-1H-naphth-1,2-dimidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases
The present invention is directed to a new pharmacological use of some known naphthoimidazole derivatives. More particularly, the compounds of the invention are 2-[2-(4-phenyl-1-piperazinyl)ethyl]-1H-naphtho-[1,2-d] imidazoles of formulawherein R is selected from methyl and 1-methylethyl and R' is selected from hydrogen, chloro, methoxy and trifluoromethyl and the pharmaceutically acceptable acid addition salts thereof and possess antihypertensive activity.
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机译:本发明涉及一些已知的萘并咪唑衍生物的新药理学用途。更特别地,本发明的化合物是下式的2- [2-(4-苯基-1-哌嗪基)乙基] -1H-萘-[1,2-d]咪唑 <图像文件=“ IMGA0001.GIF” he =“ 33” imgContent =“ chem” imgFormat =“ GIF” inline =“ no” wi =“ 87” /> Chemistry>其中R R 1选自甲基和1-甲基乙基,R'选自氢,氯,甲氧基和三氟甲基及其药学上可接受的酸加成盐,并具有降压活性。
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