Use of some 2-2-4-phenyl-1-piperazinylethyl-1H-naphth-1,2-dimidazole derivatives and their pharmaceutically acceptable salts for the manufacture of a medicament for the treatment of cardiovascular diseases

摘要

The present invention is directed to a new pharmacological use of some known naphthoimidazole derivatives. More particularly, the compounds of the invention are 2-[2-(4-phenyl-1-piperazinyl)ethyl]-1H-naphtho[1,2-d]imidazoles of formula IMAGE wherein R is selected from methyl and 1-methylethyl and R1 is selected from hydrogen, chloro, methoxy and trifluoromethyl and the pharmaceutically acceptable acid addition salts thereof and possess antihypertensive activity.