Tropez method for manufacturing a phone derivatives

摘要

NEW MATERIAL:A tropone derivative shown by the formula I (R1 is H, or lower alkyl; R2 is H, hydroxy, lower alkyl, or lower alkoxy) and its salt. EXAMPLE:4-Hydroxy-2-methyl-N-( 1-oxo-2, 4, 6-cycloheptatrien-2-yl )-2H-1,2-benzothiazine-3-carboxamido-1,1-dioxide. USE:Having anti-inflammatory action and useful as a drug. PREPARATION:A compound shown by the formula II is reacted with a compound shown by the formula III in a solvent such as preferably methanol, etc. at room temperature or under heating at about the boiling point of the solvent, to give a compound shown by the formula I . When the compound shown by the formula II of a raw material is used in a state of free acid or salt, the reaction is carried out in the presence of an alkali, and when the compound shown by the formula II is used in an ester state, the reaction is preferably carried out in the presence of an alkali metal alkoxide.