Aryl benzo method of producing a derivative Tia sleepy

摘要

NEW MATERIAL:A 2-aryl-benzothiazoline derivative expressed by formula I (R1 is lower alkanoyl or formyl; R2 is one or plural groups selected from H, lower alkyl, lower alkoxyl, hydroxy, halogen, nitro, halogeno lower alkyl or sulfamoyl; R3 is expressed by formula II or III, etc.; R4 is benzylcarbonyl, etc.; R5 is phenoxy-lower alkylene, etc.; m is an integer 1-6). EXAMPLE:3-Acetyl-2-[5-methoxy-2-{4-[ 4-( 4-methoxybenzoyl )-1-piperidyl ]butoxy} phenyl]benzothiazoline oxalate. USE:Useful as a remedy for angina pectoris, arrhythmia and thrombosis, etc. having pharmacological action, e.g. inhibitory action on blood platelet agglutin agglutination, calcium antagonistic action, etc. PREPARATION:A compuound expressed by formula IV (X is halogen) in reacted with an amine derivative expressed by formula V to afford the aimed compound expressed by formula I .