MEDICAMENTS DERIVED FROM 3-HYDROXY DODECAHYDRO BENZ(E) INDEN-7-ON, PRODUCTS DERIVED FROM 3-HYDROXY DODECAHYDRO BENZ(E) INDEN-7-ON AND PROCESS FOR THEIR PREPARATION

摘要

Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula IMAGE I wherein R is alkyl of 1 to 4 carbon atoms, R1 is alkyl of 1 to 2 carbon atoms, R2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R4 may be in the alpha -or beta -position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.