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Enantioselective synthesis of 4-amino-3-hydroxy-2,4- (disubstituted) pentanoic acid
Enantioselective synthesis of 4-amino-3-hydroxy-2,4- (disubstituted) pentanoic acid
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机译:对映选择性合成4-氨基-3-羟基-2,4-(二取代)戊酸
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摘要
4-Amino-3-hydroxy-2,4-(disubstituted)pentanoic acids of the formula: ##STR1## useful as intermediates in preparing antibacterial compounds, are synthesized enantiospecifically by acylation of a chiral enolate with an optically active acylating agent. The resulting product is reduced stereospecifically to afford a protected form of the desired product, which contains three adjacent asymmetric centers of known configuration. The synthesis may be illustrated as follows: ##STR2##
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