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(-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers
(-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers
A method for providing orally effective aporphine compounds, and new compounds which are orally effective in the prevention and treatment of duodenal ulcers and in the treatment of neurological and psychiatric disorders having the following formula ##STR1## wherein R.sub. 1 is lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl and phenyl lower alkynyl, R.sub.2 and R.sub.3 are hydrogen, methyl, lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted lower alkynyl, phenyl lower alkyl, phenyl lower alkenyl and phenyl lower alkynyl and R.sub.4 is hydrogen, hydroxy, --O--R.sub.5 and ##STR2## and R. sub.5 is methyl and lower alkyl. Particularly effective are compounds wherein R.sub.4 is hydrogen.
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机译:提供具有下式的口服有效的阿芬吗啡化合物的方法以及对预防和治疗十二指肠溃疡以及神经疾病和精神疾病有效的口服有效化合物: R 1和R 2是低级烷基,取代的低级烷基,环烷基,取代的环烷基,低级烯基,取代的低级烯基,低级炔基,取代的低级炔基,苯基低级烷基,苯基低级烯基和苯基低级炔基。 3是氢,甲基,低级烷基,取代的低级烷基,环烷基,取代的环烷基,低级烯基,取代的低级烯基,低级炔基,取代的低级炔基,苯基低级烷基,苯基低级烯基和苯基低级炔基,R 4是氢,羟基,-O-R 5和R 5是甲基和低级烷基。特别有效的是其中R 4是氢的化合物。
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