UNSATURATED FATTY ACID AMIDE DERIVATIVE AND INHIBITOR OF BLOOD PLATELET AGGREGATION CONTAINING SAME

摘要

NEW MATERIAL:An unsaturated fatty acid amide derivative shown by the formula I [R1 is H, or methyl; R2 is H, or methyl, and when R1 is H, R2 is also H; m is number of double bonds in trans configuration, 1 or 2; Y is group shown by the formula II (n is 2, 4, or 4; X is acyl derived from either triene higher fatty acid or pentaene higher fatty acid), or group shown by the formula III]. E X A M P L E : 1 - [ N - [ 3 - ( 3 - Methoxy-4-hydroxy)phenyl]-2-propenoyl]-beta-aminoethyl]-4-(5,8,11,14,1 7-eicosapentaenoyl)piperazine. USE:An inhibitor of blood platelet aggregation. PREPARATION:For example, a carboxylic acid derivative shown by the formula IV (R1 is methyl, or methoxyethoxymethyl; R2 is R1) or a reactive derivative shown by the formula V is subjected to a condensation reaction and a protecting group removing reaction, to give a compound shown by the formula I.