PRODUCTION OF 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL

摘要

PURPOSE:The hydrogenation of hexafluoroacetone is carried out in the presence of a rhodium catalyst to produce in high yield the titled substance that is used as a surface active agent, emulsifier, polymer solvent, synthetic intermediate of fluorine-containing compounds and intermediate of inhalation anesthetic. CONSTITUTION:The titled substance is obtained by hydrogenation of hexafluoroacetone in the presence of a rhodium catalyst such as reduced rhodium, rhodium oxide, rhodium hydroxide, or rhodium chloride. As a catalyst, 0-valent rhodium is effective and reduced rhodium is preferred. The catalyst is generally in the form of rhodium on a support (such as activated carbon or alumina)[the content of rhodium is 0.5-10wt% based on the support (calculated as metallic rhodium)] and the reaction is preferably carried out in a gaseous or liquid system. The amount of the catalyst ued is 0.001-0.1wt% based on the starting material calculated as metallic rhodium and reaction conditions are 20-100 deg.C, 0.5- 30 atmospheric pressure in the hydrogen partial pressure and 1min to 500hr in reaction time.