ANALOGIFREMGANGSMAADE FOR THE PRODUCTION OF PEPTIDES CONTAINING 2-7 amino acid residues, DESAMINODIPEPTIDER or amides thereof having ubiquitin-like activity, or pharmaceutically acceptable acid addition salts thereof

摘要

Peptides of the following formula: A-B wherein A is a member selected from the group consisting of deamino-GLN, GLN, and (SAR)n-GLN; n is an integer from 1 to 4; and B is a member selected from the group consisting of LYS-OH, LYS-NH2, decarboxy-LYS, IMAGE LYS-SAR-OH and LYS-SAR-NH2, have significantly increased ubiquitin-like activity. Also provided are therapeutic compositions and methods for use thereof.