首页> 外国专利> TUMOERHAEMMANDE (1,2-DIPHENYL-ETHYLENDIAMINE) -Platinum (II) COMPLEX.

TUMOERHAEMMANDE (1,2-DIPHENYL-ETHYLENDIAMINE) -Platinum (II) COMPLEX.

机译:TUEMERHAEMMANDE(1,2-二苯基-乙撑亚胺)-Platinum(II)Complex。

摘要

There are disclosed antitumor active 1,2-diphenyl-ethylenediamine)-platinum(II)-complex of the general formula IMAGE I wherein R7 is hydrogen or C1-C6-alkyl and R2 is either (1) a halogen atom and the groups R1, R3, R4, R5, and R6 are the same or different and are hydrogen, halogen, trihalomethyl, C1-C6-alkyl, hydrogen C1-C6-alkoxy, a C2-C6-alkanoyloxy or a halo or C1-C4-alkanesulfonyloxy substituted C2-C6-alkanoyloxy group, or R2 is (2) a hydroxy group, a C1-C6-alkoxy group, a C2-C6-alkanoyloxy group in the 4-position or a halo or C1-C4-alkanesulfonyloxy substituted C2-C6-alkanoyloxy group and if R2 is (2) then the groups R1 and R3 which are the same or differnt are in the 2 and 6 positions of the phenyl group and are halogen, trihalomethyl, C1-C6-alkyl, hydroxy, a C1-C6-alkoxy, C2-C6-alklanoyloxy group or a halo or C1-C5-alkanesulfonyloxy substituted C2-C6-alkanoyloxy group, with the proviso that R1 can also be hydrogen and the groups R4, R5, and R6 are the same or different and are hydrogen, halogen, trihalomethyl, C1-C6-alkyl, hydroxy, C1-C6-alkoxy, a C2-C6-alkanoyloxy group or a halo or C1-C4-alkanesulfonyloxy substituted C2-C6-alkanoyloxy group and X is the equivalent of a physiologically compatible anion and process of their production.
机译:公开了具有通式 I的抗肿瘤活性的1,2-二苯基-乙二胺)-铂(II)-配合物,其中R7是氢或C1-C6-烷基,R2是(1)卤素原子,且基团R 1,R 3,R 4,R 5和R 6相同或不同,并且是氢,卤素,三卤甲基,C 1 -C 6烷基,氢C 1 -C 6烷氧基,C 2 -C 6烷酰氧基或卤素或C 1 -C 4 -烷烃磺酰氧基取代的C 2 -C 6烷酰氧基,或R 2为(2)羟基,C 1 -C 6烷氧基,4-位的C 2 -C 6烷酰氧基或卤素或C 1 -C 4烷磺酰氧基取代C 2 -C 6烷酰氧基,如果R 2为(2),则相同或不同的基团R 1和R 3在苯基的2和6位上,为卤素,三卤甲基,C 1 -C 6烷基,羟基, C 1 -C 6烷氧基,C 2 -C 6烷酰氧基或卤素或C 1 -C 5烷磺酰氧基取代的C 2 -C 6烷酰氧基,条件是R 1也可以是氢并且R 4,R 5和R 6是基团。相同或不同nd是氢,卤素,三卤甲基,C1-C6-烷基,羟基,C1-C6-烷氧基,C2-C6-烷酰氧基或卤素或C1-C4-链烷磺酰氧基取代的C2-C6-烷酰氧基,且X为等价基团生理相容性阴离子的制备及其制备方法。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号