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substituerade 1.8 - naftyridinoner, foerfarande foer deras framstaellning och farmaceutiska blandningar innehaollande year.
substituerade 1.8 - naftyridinoner, foerfarande foer deras framstaellning och farmaceutiska blandningar innehaollande year.
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机译:取代1.8-萘啶酮,其制备方法及所含药物混合物。
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摘要
Substituted 1,8-naphthyridinones of formulae V, VI or VII CHEM wherein n is 1 or 2; R1 and R2 may be combined to form a bond, or R1 is hydrogen and R2 is OR, halogen or NR3R4; R is hydrogen, carboxylic acyl or carbamyl; R3 and R4 are independently hydrogen or alkyl having from 1 to 6 carbon atoms, or R3 and R4 may be combined with the nitrogen to which they are attached to form a pyrrolidino, piperidino, morpholino or piperazino ring; R5 is hydrogen or carboxylic acyl; and Y is CH or N. The compounds possess anti-allergic, anti-inflammatory, cytoprotective activity and an immuno-suppressing effect.
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机译:取代的具有化学式V,VI或VII的1,8-萘啶酮,其中n为1或2; R 1和R 2可以结合形成键,或者R 1为氢,R 2为OR,卤素或NR 3 R 4; R为氢,羧基或氨基甲酰基; R 3和R 4独立地是氢或具有1-6个碳原子的烷基,或者R 3和R 4可以与它们所连接的氮结合形成吡咯烷基,哌啶子基,吗啉代或哌嗪子环; R 5为氢或羧基。该化合物具有抗过敏,抗炎,细胞保护活性和免疫抑制作用。
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